Sendurai Mani
Sendurai A. Mani | |
|---|---|
 Sendurai Mani in 2021 | |
| Born | Sendurai, Tamil Nadu, India |
| Nationality | American |
| Alma mater | Madurai Kamaraj University Indian Institute of Science Massachusetts Institute of Technology |
| Known for | EMT Cancer stem cells |
| Awards | Fellow of The American Association for the Advancement of Science |
| Scientific career | |
| Fields | Molecular Biology, Oncology, and Genetics |
| Institutions | Whitehead Institute MD Anderson Cancer Center Brown University |
| Doctoral advisor | Govindarajan Padmanaban |
| Website | mani |
Sendurai A. Mani is an Indian-American oncologist and a Molecular Bilogist. He is a fellow of the American Association for the Advancement of Sciences,[1] and Dean's Chair for Translational Oncology at Brown University Warren Alpert Medical School. He is also the associate director for Translational Oncology at the Legorreta Cancer Center at Alpert Medical School, Brown University. Previously, he was a co-director of Metastasis Research Center and co-director, the Center for Stem Cell & Developmental Biology, and a professor of Translational Molecular Pathology at MD Anderson Cancer Center.[2]
Biography[edit]
Sendurai Mani was born in a small town in the southern Indian state of Tamil Nadu. His parents never received a formal education, and are farmers. He completed his bachelor's and master's degrees at the Madurai Kamaraj University. Dr. Mani was then accepted with a scholarship at the Indian Institute of Science. There he earned a Ph.D. in Biochemistry and Molecular Biology under Professor Govindarajan Padmanabhan, a former director of the Indian Institute of Science. Dr. Mani was the first person from his hometown to earn a doctorate degree.[3]
Dr. Mani then pursued postdoctoral work at the Whitehead Institute / Massachusetts Institute of Technology under the mentorship of Professor Robert Weinberg. As a postdoctoral fellow in the Weinberg lab Dr. Mani and his colleague Jing Yang demonstrated that the latent embryonic program known as the Epithelial-Mesenchymal Transition (EMT) is critical for the development of metastasis.[4][5]
Dr. Mani joined the faculty of MD Anderson Cancer Center, Houston, Texas in 2007 and was promoted to Professor with Tenure. In 2022, Dr. Mani was appointed as an associate director for Translational Oncology at Legorreta Cancer Center, at Brown University and a professor of Pathology and Laboratory Medicine at Warren Alpert Medical School at Brown University, Providence, Rhode Island.
Dr. Mani's laboratory investigates how cancer cells develop to become metastatic. Dr. Mani was the first to demonstrate that cancer cells acquire stem cell properties by activating the EMT program, which allows them to survive better in the blood and establish a metastasis histopathologically similar to that of the parental primary tumor.[6][7] In this highly influential article, Dr. Mani and colleagues identified various novel attributes of metastatic cancer cells and provided the foundation and an explanation for the presence of cellular plasticity within the tumor.[8] Dr. Mani and his team continue to investigate ways to treat metastasis.[9][10]
Dr. Mani spoke at TEDx Providence in 2023 about "Why do people get cancer, how it spreads, and how to prevent it? Dr. Mani co-founded SathGen Biotech, a subdivision of Godavari Biorefineries, with Mr. Samir Somaiya of Somaiya Group, Mumbai, India and he co-founded Iylon Precision Oncology with Dr. Sewanti Limaye.[11]
Honors[edit]
- V-Scholar Award from the V Foundation[12]
- The American Cancer Society Research Scholar Award [citation needed]
- Elected member of the Scientific Research Honor Society Sigma Xi[13]
- Elected fellow of the American Association for the Advancement of Sciences (AAAS)[14]
References[edit]
- ^ "AAAS Announces Leading Scientists Elected as 2020 Fellows - The ASCO Post". The ASCO Post. Retrieved 28 November 2021.
- ^ "Sendurai A. Mani". MD Anderson Cancer Center.
- ^ Gilmore, Ron. "In life and in the lab, he never gives up". MD Anderson Cancer Center.
- ^ "Embryonic pathway delivers stem cell traits". Whitehead Institute of MIT.
- ^ Yang, Jing; Mani, Sendurai A; Donaher, Joana Liu; Ramaswamy, Sridhar; Itzykson, Raphael A; Come, Christophe; Savagner, Pierre; Gitelman, Inna; Richardson, Andrea; Weinberg, Robert A (25 June 2004). "Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis". Cell. 117 (7): 927–939. doi:10.1016/j.cell.2004.06.006. ISSN 0092-8674.
- ^ "Decoding the emergence of metastatic cancer stem cells". EurekAlert!.
- ^ Mani, S. A.; Guo, W.; Liao, M. J.; Eaton, E. N.; Ayyanan, A.; Zhou, A. Y.; Brooks, M.; Reinhard, F.; Zhang, C. C.; Shipitsin, M.; Campbell, L. L.; Polyak, K.; Brisken, C.; Yang, J.; Weinberg, R. A. (2008). "The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells". Cell. 133 (4): 704–15. doi:10.1016/j.cell.2008.03.027. PMC 2728032. PMID 18485877.
- ^ "Embryonic pathway delivers stem cell traits". MIT News.
- ^ "Marker to identify, attack breast cancer stem cells discovered". ScienceDaily. Retrieved 28 November 2021.
- ^ "Breakthroughs seen in cancer spread and stem cells". The New York Times. 9 September 2008. ISSN 0362-4331. Retrieved 28 November 2021.
- ^ "Iylon – Precision Oncology". Iylon – Precision Oncology. Retrieved 28 November 2021.
- ^ "Grants Awarded for Texas". V Foundation. Retrieved 28 November 2021.
- ^ "Member Directory". Sigma Xi. Retrieved 28 November 2021.
- ^ "AAAS announces leading scientists elected as 2020 fellows (contd.)". EurekAlert!.
External links[edit]
- Sendurai Mani publications indexed by Google Scholar
- Sendurai Mani lab website at Brown University
- Sendurai Mani's TEDx talk at Providence
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