CRB3

CRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5I7Z
Identifiers
Aliases	CRB3, crumbs 3, cell polarity complex component, crumbs cell polarity complex component 3
External IDs	OMIM: 609737; MGI: 2670904; HomoloGene: 138188; GeneCards: CRB3; OMA:CRB3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 6,463,777 bp End 6,467,221 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 D Start 57,366,105 bp End 57,372,918 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava body of pancreas parotid gland body of tongue pylorus skin of abdomen duodenum kidney amniotic fluid trachea Top expressed in yolk sac secondary oocyte duodenum stomach morula pyloric antrum mucous cell of stomach intestinal villus gallbladder ileum More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding protein binding protein domain specific binding Cellular component integral component of membrane cell junction plasma membrane apical part of cell extracellular exosome apical plasma membrane membrane bicellular tight junction protein-containing complex Biological process protein localization to plasma membrane bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 92359 224912 Ensembl ENSG00000130545 ENSMUSG00000044279 UniProt Q9BUF7 Q8QZT4 RefSeq (mRNA) NM_139161 NM_174881 NM_174882 NM_177638 NM_001347408 NM_001359813 NM_001359814 RefSeq (protein) NP_631900 NP_777377 NP_777378 NP_001334337 NP_808306 NP_001346742 NP_001346743 Location (UCSC) Chr 19: 6.46 – 6.47 Mb Chr 17: 57.37 – 57.37 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.

Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

External links

• Human CRB3 genome location and CRB3 gene details page in the UCSC Genome Browser.

Further reading

• Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". The Journal of Biological Chemistry. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
• Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
• Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". Journal of Cell Science. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
• Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Molecular Biology of the Cell. 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMC 363137. PMID 14718572.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells". Journal of Cell Science. 118 (Pt 13): 2859–69. doi:10.1242/jcs.02412. PMID 15976445.
• Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology. 178 (3): 387–98. doi:10.1083/jcb.200609096. PMC 2064851. PMID 17646395.