Precision cut kidney slices

Precision-cut kidney slices refer to thin sections of the kidney tissue that are prepared with high precision to study kidney functions, drug metabolism or disease processes. Researchers use these slices to study the impact of substances on renal function.^[1]^[2] This includes drug metabolism^[3]^[4] and the effects of toxic substances.^[5]

References[edit]

^ Poosti, Fariba; Pham, Bao Tung; Oosterhuis, Dorenda; Poelstra, Klaas; van Goor, Harry; Olinga, Peter; Hillebrands, Jan-Luuk (2015-01-01). "Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo". Disease Models & Mechanisms. 8 (10): 1227–1236. doi:10.1242/dmm.020172. ISSN 1754-8411. PMC 4610232. PMID 26112172.
^ Genovese, Federica; Kàrpàti, Zsolt S.; Nielsen, Signe H.; Karsdal, Morten A. (2016). "Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis". Biomarker Insights. 11: 77–84. doi:10.4137/BMI.S38439. PMC 4877083. PMID 27257368.
^ Graaf, Inge AM de; Groothuis, Geny MM; Olinga, Peter (2007). "Precision-cut tissue slices as a tool to predict metabolism of novel drugs". Expert Opinion on Drug Metabolism & Toxicology. 3 (6): 879–898. doi:10.1517/17425255.3.6.879. PMID 18028031. S2CID 36518505.
^ De Kanter, R.; Olinga, P.; De Jager, M.H; Merema, M.T; Meijer, D.K.F; Groothius, G.M.M (1999). "Organ Slices as an in Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney". Toxicology in Vitro. 13 (4–5): 737–744. doi:10.1016/S0887-2333(99)00047-8. PMID 20654543.
^ Parrish, Alan R.; Gandolfi, A.Jay; Brendel, Klaus (1995). "Precision-cut tissue slices: Applications in pharmacology and toxicology". Life Sciences. 57 (21): 1887–1901. doi:10.1016/0024-3205(95)02176-J. PMID 7475939.

[1] Poosti, Fariba; Pham, Bao Tung; Oosterhuis, Dorenda; Poelstra, Klaas; van Goor, Harry; Olinga, Peter; Hillebrands, Jan-Luuk (2015-01-01). "Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo". Disease Models & Mechanisms. 8 (10): 1227–1236. doi:10.1242/dmm.020172. ISSN 1754-8411. PMC 4610232. PMID 26112172.

[2] Genovese, Federica; Kàrpàti, Zsolt S.; Nielsen, Signe H.; Karsdal, Morten A. (2016). "Precision-Cut Kidney Slices as a Tool to Understand the Dynamics of Extracellular Matrix Remodeling in Renal Fibrosis". Biomarker Insights. 11: 77–84. doi:10.4137/BMI.S38439. PMC 4877083. PMID 27257368.

[3] Graaf, Inge AM de; Groothuis, Geny MM; Olinga, Peter (2007). "Precision-cut tissue slices as a tool to predict metabolism of novel drugs". Expert Opinion on Drug Metabolism & Toxicology. 3 (6): 879–898. doi:10.1517/17425255.3.6.879. PMID 18028031. S2CID 36518505.

[4] De Kanter, R.; Olinga, P.; De Jager, M.H; Merema, M.T; Meijer, D.K.F; Groothius, G.M.M (1999). "Organ Slices as an in Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney". Toxicology in Vitro. 13 (4–5): 737–744. doi:10.1016/S0887-2333(99)00047-8. PMID 20654543.

[5] Parrish, Alan R.; Gandolfi, A.Jay; Brendel, Klaus (1995). "Precision-cut tissue slices: Applications in pharmacology and toxicology". Life Sciences. 57 (21): 1887–1901. doi:10.1016/0024-3205(95)02176-J. PMID 7475939.

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