Alexey G. Ryazanov
Alexey G. Ryazanov | |
|---|---|
 | |
| Born | October 14, 1962 |
| Scientific career | |
| Fields | Pharmacology, Molecular Biology, Biochemistry |
Alexey G. Ryazanov (born October 14, 1962) is a USSR-born scientist who discovered protein alpha-kinases, professor of Pharmacology at Rutgers University. The team led by Ryazanov discovered a new class of protein kinases — alpha-kinases.[1] One of the alpha-kinases, elongation factor-2 kinase (eEF2 kinase), can regulate the global protein synthesis rate and is implicated in cancer and aging.[1]
Early life[edit]
Alexey G. Ryazanov was born on October 14, 1962.[citation needed]
Career[edit]
He is a biochemist and molecular biologist who discovered alpha-kinases,[2] a class of protein kinases that include elongation factor-2 kinase (eEF2K)[3] and channel-kinases TRPM6 and TRPM7.
Ryazanov and his colleagues demonstrated that eEF2K is a regulator of global protein synthesis[1] that plays a key role in the maintenance of quality and immortality of germ cells.[4] His laboratory also demonstrated that channel-kinase TRPM7 plays the central role in magnesium homeostasis.[5]
Alexey Ryazanov was a student of Alexander S. Spirin and worked with him at the Institute of Protein Research. He is currently Professor of Pharmacology at Robert Wood Johnson Medical School.[6]
Between 2009 and 2013 Ryazanov and Alexander Chikunov conducted a large-scale study where they tested the effect of the large variety of drugs currently used in medicine on the lifespan of long-lived mice. This study which was conducted at the Jackson Laboratory revealed the major pharmacological mechanisms that can delay aging and extend lifespan.[7]
Scientific work and awards[edit]
- Structure/Function of EFF-2 Kinase, Ryazanov Alexey, RWJ-Pharmacology-PICS
- The Role of EF-2 Kinase in Drug Resistance, Ryazanov Alexey, RWJ-Pharmacology-PISC
- The Role of Protein Turnover in Aging, Ryazanov Alexey RWJ-Pharmacology-PISC
- Project 1 Structure and Function of TRPM6/7 Ion Channel Domains, Ryazanov Alexey, Fleig Andrea, Stokes John, Scharenberg Andrew, Yang Baoli, RWJ-Pharmacology-PISC
- Development of New Drugs that Protect Gastrointestinal Tract from Radiation, Ryazanov Alexey, RWJ-Pharmacology-PISC
- Translational Control of Radiation-Induced Apoptosis, Ryazanov Alexey, RWJ-Pharmacology-PISC
- Investigation of synergism between mTOR and eEF2 kinase pathways, Ryazanov Alexey, RWJ-Pharmacology-PISC
- Use of EF2K Inhibitors to Reduce Toxicity to Normal Tissues in Chemotherapy, Ryazanov Alexey, RWJ-Pharmacology-PICS
- Use of EF2K inhibitors to inhibit tumor growth and sensitize cancer cells to existing chemotherapy treatment, Ryazanov Alexey, RWJ-Pharmacology-PISC
References[edit]
- ^ a b c Ryazanov, Alexey G.; Shestakova, Elena A.; Natapov, Pavel G. (1988-07-14). "Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation". Nature. 334 (6178): 170–173. Bibcode:1988Natur.334..170R. doi:10.1038/334170a0. ISSN 1476-4687. PMID 3386756. S2CID 4246244.
- ^ Ryazanov, Alexey G.; Ward, Michael D.; Mendola, Charmaine E.; Pavur, Karen S.; Dorovkov, Maxim V.; Wiedmann, Martin; Erdjument-Bromage, Hediye; Tempst, Paul; Parmer, Toni Gestone; Prostko, C. Robert; Germino, F. Joseph (1997-05-13). "Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase". Proceedings of the National Academy of Sciences. 94 (10): 4884–4889. Bibcode:1997PNAS...94.4884R. doi:10.1073/pnas.94.10.4884. ISSN 0027-8424. PMC 24600. PMID 9144159.
- ^ Ryazanov, Alexey G. (2002-03-06). "Elongation factor-2 kinase and its newly discovered relatives". FEBS Letters. 514 (1): 26–29. doi:10.1016/S0014-5793(02)02299-8. ISSN 0014-5793. PMID 11904175. S2CID 35720655.
- ^ Chu, Hsueh-Ping; Liao, Yi; Novak, James S.; Hu, Zhixian; Merkin, Jason J.; Shymkiv, Yuriy; Braeckman, Bart P.; Dorovkov, Maxim V.; Nguyen, Alexandra; Clifford, Peter M.; Nagele, Robert G. (2014-03-10). "Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes". Developmental Cell. 28 (5): 561–572. doi:10.1016/j.devcel.2014.01.027. ISSN 1534-5807. PMC 4712648. PMID 24582807.
- ^ Ryazanova, Lillia V.; Rondon, Lusliany J.; Zierler, Susanna; Hu, Zhixian; Galli, Joanna; Yamaguchi, Terry P.; Mazur, Andrzej; Fleig, Andrea; Ryazanov, Alexey G. (2010-11-02). "TRPM7 is essential for Mg 2+ homeostasis in mammals". Nature Communications. 1 (1): 109. Bibcode:2010NatCo...1..109R. doi:10.1038/ncomms1108. ISSN 2041-1723. PMC 3060619. PMID 21045827.
- ^ "Alexey Ryazanov". Rutgers, The State University of New Jersey. Retrieved 2021-03-29.
- ^ "JAX Notes, Winter 2010, No. 516". CiteSeerX 10.1.1.600.1584.