SAA4

SAA4
Identifiers
Aliases	SAA4, C-SAA, CSAA, serum amyloid A4, constitutive
External IDs	OMIM: 104752; MGI: 98224; GeneCards: SAA4; OMA:SAA4 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.1 Start 18,231,355 bp End 18,236,802 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 30.53 cM Start 46,377,422 bp End 46,382,027 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver minor salivary glands anterior pituitary thymus gastrocnemius muscle appendix gallbladder left uterine tube right adrenal gland right lung Top expressed in left lobe of liver gallbladder thoracic diaphragm ureter proximal tubule yolk sac muscle of leg jejunum pancreas duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function chemoattractant activity Cellular component extracellular region extracellular exosome high-density lipoprotein particle extracellular space Biological process cell chemotaxis acute-phase response positive chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6291 20211 Ensembl ENSG00000148965 ENSMUSG00000040017 UniProt P35542 P31532 RefSeq (mRNA) NM_006512 NM_011316 RefSeq (protein) NP_006503 NP_035446 Location (UCSC) Chr 11: 18.23 – 18.24 Mb Chr 7: 46.38 – 46.38 Mb PubMed search
Wikidata
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Serum amyloid A4, constitutive is a protein that in humans is encoded by the SAA4 gene.

Further reading

• Kumon Y, Suehiro T, Faulkes DJ, Hosakawa T, Ikeda Y, Woo P, et al. (November 2002). "Transcriptional regulation of serum amyloid A1 gene expression in human aortic smooth muscle cells involves CCAAT/enhancer binding proteins (C/EBP) and is distinct from HepG2 cells". Scandinavian Journal of Immunology. 56 (5): 504–11. doi:10.1046/j.1365-3083.2002.01169.x. PMID 12410800. S2CID 12571753.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, et al. (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Murphy CL, Wang S, Kestler DP, Stevens FA, Weiss DT, Solomon A (2009). "AA amyloidosis associated with a mutated serum amyloid A4 protein". Amyloid. 16 (2): 84–8. doi:10.1080/13506120902879905. PMID 20536400. S2CID 205766178.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, et al. (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, et al. (December 2010). "Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease". Journal of Lipid Research. 51 (12): 3524–32. doi:10.1194/jlr.P008268. PMC 2975725. PMID 20855565.
• Chen CL, Lin TS, Tsai CH, Wu CC, Chung T, Chien KY, et al. (June 2013). "Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics". Journal of Proteomics. 85: 28–43. doi:10.1016/j.jprot.2013.04.024. PMID 23631828.
• Rossmann C, Hammer A, Koyani CN, Kovacevic A, Siwetz M, Desoye G, et al. (August 2014). "Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells". Placenta. 35 (8): 661–4. doi:10.1016/j.placenta.2014.05.012. PMC 4119475. PMID 24951172.
• Seok A, Lee HJ, Lee S, Lee J, Mun S, Park A, et al. (May 2017). "Identification and Validation of SAA4 as a Rheumatoid Arthritis Prescreening Marker by Liquid Chromatography Tandem-mass Spectrometry". Molecules. 22 (5): 805. doi:10.3390/molecules22050805. PMC 6154608. PMID 28505104.