Taurochenodeoxycholic acid
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Names | |
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IUPAC name
2-(3α,7α-Dihydroxy-5β-cholan-24-amido)ethane-1-sulfonic acid
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Systematic IUPAC name
2-{(4R)-4-[(1R,3aS,3bR,4R,5aS,7R,9aS,9bS,11aR)-4,7-Dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanamido}ethane-1-sulfonic acid | |
Other names
12-Deoxycholyltaurine; 12-Desoxycholyltaurine; Chenodeoxycholyltaurine; Chenyltaurine
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C26H45NO6S | |
Molar mass | 499.71 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Taurochenodeoxycholic acid is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine.[1] It is secreted into bile and then into the intestine.[2] It is usually ionized at physiologic pH. However, although it can be crystallized as the sodium salt.
It acts as a detergent to solubilize fats in the small intestine and is itself absorbed by active transport in the terminal ileum.[3]
It is used as a cholagogue and choleretic.
See also[edit]
- Tauroursodeoxycholic acid, an epimer
- See article about Taurodeoxycholic acid as an interferent in Perfluorooctanesulfonic acid (PFOS) mass spectrometry analysis.
References[edit]
- ^ Hofmann AF (1999). "The continuing importance of bile acids in liver and intestinal disease". Arch. Intern. Med. 159 (22): 2647–58. doi:10.1001/archinte.159.22.2647. PMID 10597755. S2CID 21211064.
- ^ Perez de la Cruz Moreno M, Oth M, Deferme S, Lammert F, Tack J, Dressman J, Augustijns P (August 2006). "Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum". The Journal of Pharmacy and Pharmacology. 58 (8): 1079–89. doi:10.1211/jpp.58.8.0009. PMID 16872555.
- ^ Carey MC, Small DM (October 1972). "Micelle formation by bile salts. Physical-chemical and thermodynamic considerations". Archives of Internal Medicine. 130 (4): 506–27. doi:10.1001/archinte.1972.03650040040005. PMID 4562149.